Open Access publishing ensures that all the contents are immediately available to anyone free of charge. All the papers published in Highlights of Clinical Medicine are in the format of full open access. APCs are collected to finance the journal management, the whole publication and archiving process, e.g., peer-review, copy-editing, typesetting, the publishing website hosting and long-term archiving. Reviewers who submit good review reports in a timely manner will receive discount vouchers. They can use these discount vouchers to get a reduced APC.