Salk Institute for Biological Studies, La Jolla, CA 92037, USA cardiac biology; cardiac hypertrophy; myocardial fibrosis; heart failure pathophysiology; myocardial ischemia repercussion injury; beta adrenergic signaling; cardiomyocyte apoptosis; cardiomyocyte death; cardiomyocyte necrosis; oxidative stress; protein kinase A; regulatory subunit type 1α (RIa) of the cAMP-dependent protein kinase A (PKA); Prkar1a; single cell RNA sequencing; spatial transcriptomics; calcium handling; cellular biology; molecular biology